KETAMINE INFUSIONS: PHARMACOKINETICS AND CLINICAL EFFECTS
نویسندگان
چکیده
منابع مشابه
Ketamine infusions: pharmacokinetics and clinical effects.
The clinical effects and pharmacokinetics of ketamine, administered as an i.v. infusion, were studied in 31 patients. Anaesthesia was induced with ketamine 2 mg kg-1 i.v. and maintained using an i.v. infusion of ketamine, supplemented by nitrous oxide. The plasma concentrations of ketamine, nor-ketamine and dehydro-nor-ketamine were analysed using gas-liquid chromatography. The average maintena...
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BACKGROUND Central sensitization is a potential severe consequence of invasive surgical procedures. It results in postoperative and potentially chronic pain enhancement. It results in postoperative pain enhancement; clinically manifested as hyperalgesia and allodynia. N-methyl-D-aspartate (NMDA) receptor plays a crucial role in the mechanism of central sensitisation. Ketamine is most commonly u...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1979
ISSN: 0007-0912
DOI: 10.1093/bja/51.12.1167